Mashpee is conveniently located on the southeast coast of Cape Cod, ten miles east of Falmouth and ten miles west of Hyannis. Boston and Providence are approximately 70 miles to the north and west respectively.

Travelers from Boston and points north should take Route 3 south to the Sagamore Bridge and continue on Route 6, also called the Mid-Cape Highway, to Route 130 which leads to Mashpee.

From Providence and points west, take Interstate 195 to 495 and cross the Bourne Bridge. Proceed on Route 28 to Route 151 and soon you will arrive at the Mashpee rotary.

The Barnstable Municipal Airport is located in Hyannis. Bus connections to Hyannis and Falmouth can be made in Boston and New York.